Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Inflammation01:38

Inflammation

53.4K
Overview
53.4K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

811
The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
811
Vascular Resistance01:20

Vascular Resistance

3.9K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Total Saponins of Panax Notoginseng Leaves Modulate the "Microglial-NLRP3/Caspase-1" Axis associated with Gut Microbial/SCFAs Alterations: Correlative Insights into Cognitive Improvement in Senescence.

Molecular neurobiology·2026
Same author

Discovery of cis-Gnetin H from peony seed coat as a potent antifibrotic agent modulating hepatic fibro-inflammatory pathways and gut microbiota homeostasis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

[Bidirectional regulation of ischemic myocardium and atherosclerotic plaque by Qixue Bingzhi Formula: role of angiogenesis in coronary heart disease and related mechanism].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

Hallmarks of health: A Chinese medicine perspective.

Innovation (Cambridge (Mass.))·2026
Same author

Ecophysiological Characteristics of High-Photosynthetic-Efficiency Rice Varieties and Their Environmental Regulation.

Physiologia plantarum·2026
Same author

Correlation Between Fat Attenuation Index and Major Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis.

Reviews in cardiovascular medicine·2026

Related Experiment Video

Updated: Jun 30, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K

Vascular Aging and Atherosclerosis: A Perspective on Aging.

Shudong Ma1,2, Xuena Xie3,2, Rong Yuan2,4

  • 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.

Aging and Disease
|March 19, 2024
PubMed
Summary

Vascular aging accelerates atherosclerosis by promoting cellular senescence and dysfunction. Understanding these aging mechanisms is key to preventing cardiovascular disease progression.

More Related Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

889
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.8K

Related Experiment Videos

Last Updated: Jun 30, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

889
Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.8K

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Cellular Biology

Background:

  • Vascular aging (VA) is a significant contributor to atherosclerosis (AS) development.
  • Existing research highlights a strong link between aging and AS, but underlying mechanisms need further exploration.

Purpose of the Study:

  • To examine the relationship between biological aging, vascular cell senescence, and atherosclerosis from an aging-centric viewpoint.
  • To elucidate the intricate mechanisms linking aging processes to vascular health and AS.

Main Methods:

  • Review of epidemiological and clinical research on vascular aging and atherosclerosis.
  • Analysis of aging-related physiological factors impacting vascular function.
  • Investigation into the role of senescent cells in vascular tissues.

Main Results:

  • Aging-related factors (e.g., oxidative stress, inflammation, lipids) contribute to endothelial dysfunction and AS.
  • Increased senescent cells in vascular tissues may be a primary driver of VA.
  • Shared and distinct pathways link VA and AS progression.

Conclusions:

  • Vascular aging is a critical factor in atherosclerosis.
  • Cellular senescence in the vasculature is a key mechanism driving vascular aging and AS.
  • Further research into these aging mechanisms can inform therapeutic strategies for AS.