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Updated: Jun 30, 2025

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Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.

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Vulvar cancer, predominantly squamous cell carcinoma, affects thousands annually. Guidelines offer recommendations for treatment, surveillance, and survivorship for this gynecologic malignancy.

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Area of Science:

  • Gynecologic Oncology
  • Dermatopathology
  • Oncology

Background:

  • Vulvar cancer is a rare gynecologic malignancy, accounting for 5-8% of cases.
  • Squamous cell carcinoma is the predominant histology, with rarer types including melanoma and sarcoma.
  • Risk factors include HPV infection, smoking, and immunodeficiency.

Purpose of the Study:

  • To summarize the NCCN Clinical Practice Guidelines for vulvar cancer.
  • To provide recommendations on treatment, surveillance, and systemic therapy.
  • To address gynecologic survivorship issues in vulvar cancer patients.

Main Methods:

  • Review of NCCN Clinical Practice Guidelines for vulvar cancer.
  • Synthesis of current evidence and expert consensus.
  • Focus on treatment, surveillance, and survivorship.

Main Results:

  • Most vulvar cancers are diagnosed at early stages.
  • NCCN Guidelines provide a framework for managing vulvar cancer.
  • Recommendations cover surgical, radiation, and systemic therapies.

Conclusions:

  • Adherence to NCCN Guidelines ensures optimal management of vulvar cancer.
  • Multidisciplinary approach is crucial for effective treatment and survivorship.
  • Ongoing research is vital for improving outcomes in rare vulvar cancers.