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The role of RNA-modifying proteins in renal cell carcinoma

Muna A Alhammadi1,2, Khuloud Bajbouj3,4,5, Iman M Talaat6,7,8

  • 1Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, P.O. Box 27272, United Arab Emirates. u21107591@sharjah.ac.ae.

Cell Death & Disease
|March 20, 2024
PubMed

Insights

Epitranscriptomics, the study of RNA modifications, plays a crucial role in regulating gene expression. Aberrations in RNA-modifying proteins are linked to renal cell carcinoma development and progression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Gene expression is vital for cellular function, regulated by complex genomic, epigenomic, transcriptomic, and proteomic mechanisms.
  • Epitranscriptomics, involving chemical modifications of RNA by RNA-modifying proteins, is a newly discovered layer of gene expression control.
  • Dysregulation of RNA-modifying proteins is implicated in various diseases, including cancer.

Purpose of the Study:

  • To review the role of epitranscriptomics in the pathogenesis and progression of renal cell carcinoma (RCC).
  • To summarize the molecular functions of RNA-modifying proteins in RCC development.

Main Methods:

  • Literature review of epitranscriptomics and renal cell carcinoma.
  • Analysis of molecular functions of RNA-modifying proteins in RCC pathogenesis.

Main Results:

  • Epitranscriptomics influences mRNA splicing, nuclear export, stabilization, translation, and degradation.
  • RNA-modifying protein dysregulation is a significant factor in RCC pathogenesis.
  • Specific molecular functions of these proteins contribute to RCC progression.

Conclusions:

  • Epitranscriptomics represents a critical regulatory layer in gene expression with implications for RCC.
  • Understanding RNA-modifying proteins offers insights into RCC pathogenesis and potential therapeutic targets.

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