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Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation
Pranjal Kumar Singh1, Nidhi Singh2, Atul Pratap Singh3
1SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Delhi NCR Campus, Modinagar, Ghaziabad, Uttar Pradesh, India.
Combinatorial Chemistry & High Throughput Screening
|March 20, 2024
Summary
This review explores enhancing drug solubility using mixed solvency, a novel approach to increase poorly soluble drug dissolution. It analyzes green solvents as safer alternatives to traditional organic solvents in pharmaceutical formulations.
Area of Science:
- Pharmaceutical Science
- Green Chemistry
Background:
- Organic solvents pose hazards, necessitating safer alternatives in drug formulation.
- Improving solubility of poorly soluble drugs is a significant challenge in pharmaceutical development.
Purpose of the Study:
- To introduce the mixed solvency concept for enhancing drug solubility.
- To review green solvents as alternatives to traditional organic solvents.
- To provide scientists with novel strategies for medication solubility enhancement.
Main Methods:
- Exploration of the mixed solvency concept for drug solubilization.
- Analysis of various solubility enhancement techniques (complexation, pH modification, salt formation, hydrotropy, cosolvency, micelle solubilization).
- Evaluation of green solvents, including bio-based solvents, deep eutectic solvents, supercritical fluids, and surfactant-based solutions.
Main Results:
- Mixed solvency offers a novel approach to increase the solubility of poorly soluble drugs.
- Green solvents present viable, less harmful alternatives to conventional organic solvents.
- Reducing solubilizer concentration via mixed solvency can decrease formulation toxicity.
Conclusions:
- The mixed solvency concept provides a promising strategy for improving drug solubility.
- Green solvents are crucial for developing sustainable and safer pharmaceutical formulations.
- Further research into mixed solvency and green solvents can advance pharmaceutical development.
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