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Updated: Jun 30, 2025

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
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Trial watch: local anesthetics in cancer therapy

Killian Carnet Le Provost1,2, Oliver Kepp1,2, Guido Kroemer1,2,3

  • 1Equipe Labellisée Par La Ligue Contre Le Cancer, Université de Paris, Sorbonne Université, Centre de Recherche des Cordeliers, Institut Universitaire de France, Paris, France.

Oncoimmunology
|March 20, 2024
PubMed

Insights

Local anesthetics show promising antitumor effects by directly killing cancer cells and boosting immunity. Further clinical trials are needed to confirm their anticancer potential in humans.

Area of Science:

  • Oncology
  • Pharmacology
  • Immunology

Background:

  • Preclinical studies suggest local anesthetics possess significant antitumor properties.
  • Mechanisms include direct cytotoxicity and immune-mediated effects, reducing cancer cell proliferation, invasion, and migration.

Discussion:

  • While preclinical data is robust, prospective clinical trials are limited.
  • Methodological challenges in controlling confounding factors may explain the lack of definitive clinical confirmation.

Key Insights:

  • Local anesthetics demonstrate dual action: direct cancer cell killing and immune system modulation.
  • Evidence suggests a reduction in malignant cell proliferative, invasive, and migratory capabilities.

Outlook:

  • This review compiles preclinical and clinical research on local anesthetics' antitumor potential.
  • It includes completed and ongoing trials to assess their efficacy in cancer treatment.
Keywords:
Cancerimmunitylocal anestheticsstress

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