The Japanese Pediatric Continuous Renal Replacement Therapy (jpCRRT) Registry: Study Protocol

Area of Science:

• Pediatric Critical Care Medicine
• Nephrology
• Clinical Research Methodology

Background:

• Continuous renal replacement therapy (CRRT) use is increasing in critically ill children, yet standards of care and prognosis remain suboptimal.
• There is a lack of comprehensive data on CRRT practices and outcomes in Japanese pediatric intensive care units (PICUs).

Purpose of the Study:

• To establish the Japanese Pediatric CRRT registry, a multicenter initiative to investigate the current status of CRRT in Japanese PICUs.
• To gather data for developing optimal CRRT strategies and improving outcomes for critically ill children.

Main Methods:

• A multicenter prospective registry protocol involving 15 Japanese PICUs.
• Enrollment of patients under 16 years requiring CRRT for >24 hours, including those with extracorporeal membrane oxygenation.
• Data collection via an online registry system with primary outcomes including neurodevelopmental status (Pediatric Cerebral Performance Category Scale), dialysis dependence, and readmission.

Main Results:

• Data collection is ongoing as of April 2023.
• The registry protocol outlines primary and secondary outcomes to assess CRRT effectiveness and safety.
• The study aims to analyze outcomes across different patient and treatment groups.

Conclusions:

• This project will provide crucial insights into CRRT utilization and outcomes in Japanese PICUs.
• The findings will inform the design of future interventional studies and contribute to establishing a standardized platform for multicenter registry research.
• The ultimate goal is to improve the standard of care and prognosis for pediatric patients undergoing CRRT.