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Updated: Jun 30, 2025

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

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Predicting postoperative lung function using ventilation SPECT/CT in patients with lung cancer.

Yong Ho Jeong¹, Hyun Lee², Hyo Jun Jang³

¹Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Journal of Thoracic Disease

|March 20, 2024

Summary

Ventilation SPECT/CT effectively predicts postoperative lung function in lung cancer patients undergoing lobectomy. This imaging technique shows strong correlation with actual lung function, similar to perfusion SPECT/CT.

Keywords:

Lung neoplasms forced expiratory volume perfusion single-photon emission computed tomography (SPECT)ventilation

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Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

Published on: June 5, 2019

Area of Science:

Pulmonary Medicine
Radiology
Thoracic Surgery

Background:

Single-photon emission computed tomography/computed tomography (SPECT/CT) offers regional lung function assessment.
Predicting postoperative lung function is crucial for patients with lung cancer undergoing surgery.

Purpose of the Study:

To investigate the utility of ventilation (SPECT/CT) in predicting postoperative lung function after lobectomy in lung cancer patients.
To compare the predictive performance of ventilation SPECT/CT with perfusion SPECT/CT.

Main Methods:

Retrospective analysis of 47 lung cancer patients who underwent lobectomy and preoperative SPECT/CT (ventilation and perfusion).
Calculation of predicted postoperative forced expiratory volume in 1 second (ppoFEV₁%) and predicted postoperative diffusion capacity of the lung for carbon monoxide (ppoDL_CO%) using SPECT/CT data.
Correlation analysis between predicted and actual postoperative lung function (FEV₁% and DL_CO%).

Main Results:

Ventilation SPECT/CT demonstrated a strong correlation with perfusion SPECT/CT for both ppoFEV₁% (r=0.939) and ppoDL_CO% (r=0.938).
Predicted lung function values from both ventilation and perfusion SPECT/CT showed strong correlations with actual postoperative FEV₁% (r=0.774 and r=0.795, respectively) and DL_CO% (r=0.768 and r=0.751, respectively).

Conclusions:

Ventilation SPECT/CT is a valuable tool for predicting postoperative lung function in lung cancer patients.
The predictive accuracy of ventilation SPECT/CT is comparable to that of perfusion SPECT/CT.