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Bioinspired Soft Robot with Incorporated Microelectrodes
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Soft bioelectronics for cardiac interfaces.

Xin Tang1, Yichun He1, Jia Liu1

  • 1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, Massachusetts 02134, USA.

Biophysics Reviews
|March 20, 2024
PubMed
Summary
This summary is machine-generated.

Soft bioelectronics offer advanced interfacing with cardiac systems, overcoming limitations of rigid devices. These flexible and stretchable technologies enable new methods for studying cardiac health and disease in vitro and in vivo.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cardiology

Background:

  • Conventional rigid bioelectronics face limitations in interfacing with soft cardiac tissues due to mechanical and structural mismatches.
  • Recent advancements in soft electronics have enabled the development of flexible and stretchable bioelectronic devices.

Purpose of the Study:

  • To review the development and applications of soft bioelectronics for cardiac system interrogation and intervention.
  • To highlight the potential of soft bioelectronics in both in vitro and in vivo cardiac models.

Main Methods:

  • Review of recent literature on flexible and stretchable bioelectronics for epicardial interfaces.
  • Discussion of integrating stretchable bioelectronics with cardiac catheters for minimally invasive in vivo applications.
  • Highlighting the design and integration of soft bioelectronics with in vitro cardiac models like cardiac patches and organoids.

Main Results:

  • Soft bioelectronics provide superior interfacing capabilities compared to rigid counterparts.
  • Stretchable bioelectronics integrated with cardiac catheters enable minimally invasive in vivo cardiac monitoring.
  • Soft bioelectronics facilitate detailed interrogation of cardiac activity in various in vitro models.

Conclusions:

  • Soft bioelectronics represent a significant advancement for studying cardiac health and disease.
  • These materials offer novel opportunities for both in vitro and in vivo cardiac research and clinical applications.
  • Future research directions focus on further optimizing soft bioelectronics for comprehensive cardiac system analysis.