Related Experiment Video
Updated: Jun 30, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Integrins regulation of wound healing processes: insights for chronic skin wound therapeutics
Dong Yu1,2, Zhaoyu Lu1,2, Fengsong Nie1,2
1Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Abstract:
Integrins are heterodimers composed of non-covalently associated alpha and beta subunits that mediate the dynamic linkage between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs and are involved in different physiological and pathological molecular responses in vivo. Wound healing is an important process in the recovery from traumatic diseases and consists of three overlapping phases: inflammation, proliferation, and remodeling. Integrin regulation acts throughout the wound healing process to promote wound healing. Prolonged inflammation may lead to failure of wound healing, such as wound chronicity. One of the main causes of chronic wound formation is bacterial colonization of the wound. In this review, we review the role of integrins in the regulation of wound healing processes such as angiogenesis and re-epithelialization, as well as the role of integrins in mediating bacterial infections during wound chronicity, and the challenges and prospects of integrins as therapeutic targets for infected wound healing.
More Related Videos
Related Concept Videos
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Intracellular Signaling Affects Focal Adhesions
Some...
Clinical Applications of Epidermal Stem Cells
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Integrins
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

