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Model construction and application for predicting pre-eclampsia by Sonoclot coagulation analyzer.

Hongyu Shi1, Weijie Wang2, Fan Li2

  • 1Endoscopic Center of the First Hospital of Jilin University, China.

Non-Coding RNA Research
|March 20, 2024
PubMed
Summary
This summary is machine-generated.

Preeclampsia diagnosis may be improved using the Sonoclot analyzer, which measures coagulation function. This study found significant differences in prothrombin time (PT) and activated clotting time (ACT) between preeclamptic and healthy women.

Keywords:
Activated clotting timeClot ratePlatelet countPlatelet functionPreeclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Medical Diagnostics

Background:

  • Maternal age is increasing, raising pregnancy complication risks.
  • Preeclampsia is a major cause of maternal and perinatal mortality.
  • Current preeclampsia diagnosis relies on clinical signs and coagulation tests with limited efficacy.

Purpose of the Study:

  • To investigate the potential of the Sonoclot coagulation analyzer for diagnosing preeclampsia.
  • To compare Sonoclot-derived parameters with routine coagulation tests in preeclamptic and non-preeclamptic women.

Main Methods:

  • Subjects were divided into preeclamptic (test) and non-preeclamptic (control) groups.
  • Sonoclot parameters (PF, ACT, CR) and routine coagulation tests (PT, APTT, TT, FIB, platelet count) were measured.
  • Regression analysis and K-fold cross-validation were used to assess diagnostic feasibility.

Main Results:

  • Significant differences in prothrombin time (PT) and activated clotting time (ACT) were observed between groups.
  • PT and ACT were identified as reliable predictors in logistic regression analysis.
  • K-fold cross-validation yielded a 77.5% accuracy rate for Sonoclot in preeclampsia diagnosis.

Conclusions:

  • The Sonoclot analyzer shows potential utility in diagnosing preeclampsia in obstetrics.
  • Further research is warranted to validate Sonoclot's role in clinical practice.
  • lncRNAs ANRIL and HOXD-AS1 were found to be deregulated in preeclampsia.