Expression profile of serum LncRNAs MALAT-1 and CCAT-1 and their correlation with Mayo severity score in ulcerative colitis patients can diagnose and predict the prognosis of the disease
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies MALAT-1 and CCAT-1 as key diagnostic and prognostic biomarkers for ulcerative colitis (UC). Elevated levels of these long noncoding RNAs in serum correlate with disease severity, offering new insights for UC management.
Area Of Science
- Genomics
- Molecular Biology
- Gastroenterology
Background
- Ulcerative colitis (UC) is a chronic condition with increasing incidence and is recognized as a precancerous lesion for colorectal cancer.
- Genomic research highlights the role of noncoding RNAs (ncRNAs) in UC pathogenesis, diagnosis, and prognosis.
Purpose Of The Study
- To measure serum levels of MALAT-1 and CCAT-1 in UC patients.
- To evaluate MALAT-1 and CCAT-1 as diagnostic and prognostic biomarkers for UC.
- To correlate these biomarkers with disease severity (Mayo score) and clinicopathological characteristics.
Main Methods
- Quantitative real-time PCR (qRT-PCR) was used to measure serum fold changes of MALAT-1 and CCAT-1.
- The study included 66 UC patients and 80 healthy controls.
- Correlation analyses were performed with Mayo score, ESR, and clinicopathological features.
Main Results
- Overexpression of MALAT-1 and CCAT-1 was observed in UC patients compared to controls.
- Both biomarkers demonstrated diagnostic capability for UC, with CCAT-1 achieving 99% accuracy via ROC analysis.
- Elevated levels of MALAT-1 and CCAT-1 significantly correlated with increased disease severity (Mayo score) and ESR.
Conclusions
- MALAT-1 and CCAT-1 are validated as significant diagnostic and prognostic serum biomarkers for ulcerative colitis.
- These long noncoding RNAs may serve as valuable indicators for monitoring UC progression and predicting outcomes.
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