Related Experiment Video
Updated: Jun 30, 2025

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Electron Transfer from Haem to the Di-Iron Ferroxidase Centre in Bacterioferritin
Jacob Pullin1, Justin M Bradley2, Geoffrey R Moore2
1School of Life Sciences University of Essex Wivenhoe Park Colchester Essex CO4 3SQ UK.
Abstract:
The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other ferritins in that they contain haem groups. It is acknowledged that the two iron motifs in bacterioferritins, the di-nuclear ferroxidase centre and the haem B group, play key roles in two opposing processes, iron sequestration and iron mobilisation, respectively, and the two redox processes are independent. Herein, we show that in Escherichia coli bacterioferritin, there is an electron transfer pathway from the haem to the ferroxidase centre suggesting a new role(s) haem might play in bacterioferritins.
Related Concept Videos
Electron Transport Chain: Complex III and IV
The Early Endosome: Endocytosis of Transferrin
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
The Electron Transport Chain
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Electron Transport Chains
The ETC is comprised of...
Role of Reduced Coenzymes NADH and FADH₂
![Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55858.jpg&w=3840&q=50)
