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Updated: Jun 30, 2025

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Transcriptome Analysis Reveals Distinct Patterns Between the Invasive and Noninvasive Pituitary Neuroendocrine

Jelena Jotanovic1,2, Abdellah Tebani3,4, Neda Hekmati1

  • 1Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden.

Journal of the Endocrine Society
|March 20, 2024
PubMed
Summary
This summary is machine-generated.

This study explored gene expression in pituitary neuroendocrine tumors (PitNETs). Invasive PitNETs show distinct molecular patterns, offering potential for new prognostic and therapeutic targets.

Keywords:
PitNETRNA-sequencinginvasivenesspathologypituitary adenomatranscriptomics

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Area of Science:

  • Endocrinology
  • Oncology
  • Genomics

Background:

  • Most pituitary neuroendocrine tumors (PitNETs) are intrasellar, but some exhibit parasellar invasion or bone infiltration, impacting prognosis.
  • Novel markers for predicting parasellar growth and understanding bone invasiveness and tumor vascularization in PitNETs are needed.

Purpose of the Study:

  • To identify gene expression differences between invasive and noninvasive PitNETs, focusing on parasellar and bone invasiveness.
  • To explore genes correlated with tumor vascularization using the contrast enhancement quotient.

Main Methods:

  • Genome-wide mRNA analysis was performed on 77 patients with various PitNET types.
  • Gene expression patterns were compared between invasive (including bone-invasive) and noninvasive tumors.
  • Correlation analysis was conducted between gene expression and the contrast enhancement quotient.

Main Results:

  • Genes involved in tumor invasiveness were differentially expressed in parasellar invasive PitNETs.
  • Genes linked to the NF-κB pathway and antitumoral immune response were associated with bone invasiveness.
  • The contrast enhancement quotient correlated with several angiogenesis-related genes, indicating its role in assessing tumor vascularization.

Conclusions:

  • Transcriptomics revealed molecular differences between invasive and noninvasive PitNETs, though clear clustering was absent.
  • Identified genes related to PitNET invasiveness and vascularization hold potential for future prognostic and therapeutic strategies.
  • Further research is warranted to validate the clinical applicability of these findings.