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Association Areas of the Cortex

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

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Related Experiment Video

Updated: Jun 30, 2025

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Human striatal association megaclusters.

Heather L Kosakowski¹, Noam Saadon-Grosman¹, Jingnan Du¹

¹Department of Psychology, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States.

Journal of Neurophysiology

|March 20, 2024

Summary

This summary is machine-generated.

The caudate nucleus, part of the basal ganglia, contains distinct regions linked to five association networks, mirroring cerebral cortex organization. This discovery reveals fine-grained network segregation within the caudate, enhancing our understanding of brain function.

Keywords:

association cortex basal ganglia fMRI functional connectivity striatum

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Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations

Published on: February 15, 2017

Area of Science:

Neuroscience
Cognitive Neuroscience
Neuroimaging

Background:

The striatum, particularly the caudate nucleus, receives cortical projections, supporting diverse brain functions.
Previous research suggests specialized basal ganglia circuits, but detailed organization remains under investigation.

Purpose of the Study:

To investigate the detailed organization of the caudate nucleus using high-resolution neuroimaging.
To determine if the caudate nucleus mirrors the specialized network organization found in the cerebral cortex.

Main Methods:

Utilized within-individual precision neuroimaging on multiple participants (initially 2, then 15 more).
Analyzed functional connectivity between caudate regions and distributed association networks in the cortex.
Examined laterality and spatial organization of identified caudate regions.

Main Results:

Identified five distinct 'striatal association megaclusters' within the caudate, each coupled to specific cortical association networks.
Confirmed that these caudate networks recapitulate the organization and spatial distribution of their cortical counterparts.
Observed asymmetries in caudate megaclusters, including leftward lateralization for language-related regions, mirroring cortical patterns.

Conclusions:

The caudate nucleus exhibits fine-grained segregation of multiple higher-order cognitive networks, reflecting cerebral cortex organization.
This detailed organization extends the understanding of specialized basal ganglia circuits.
The findings highlight parallel organizational principles between the striatum and cerebral cortex.