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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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[Endothelial dysfunction as a pathogenetic factor of sensorineural hearing loss]

V V Noskova1, A N Khrabrikov1

  • 1Kirov State Medical University, Kirov, Russia.

Vestnik Otorinolaringologii
|March 20, 2024
PubMed

Insights

Chronic sensorineural hearing loss (SNHL) is linked to microangiopathy, with endothelial dysfunction (ED) initiating inner ear vessel changes. Further research clarifies the etiopathogenesis of hearing loss, focusing on ED

Area of Science:

  • Otolaryngology
  • Vascular Biology
  • Pathophysiology

Context:

  • Chronic sensorineural hearing loss (SNHL) is a significant cause of disability.
  • The precise pathogenesis of SNHL remains incompletely understood.
  • Microangiopathy is increasingly implicated in SNHL development.

Purpose:

  • To review recent scientific research on the etiopathogenesis of SNHL.
  • To examine the role of endothelial dysfunction (ED) in auditory disorders.
  • To consolidate understanding of ED's contribution to SNHL.

Summary:

  • Endothelial dysfunction (ED) is a key factor triggering pathological changes in inner ear vessels.
  • ED initiates a cascade of events contributing to the development of microangiopathy in SNHL.
  • This review synthesizes current knowledge on ED's role in the pathophysiology of SNHL.

Impact:

  • Provides a comprehensive overview of ED in SNHL pathogenesis.
  • Highlights the critical role of vascular health in maintaining auditory function.
  • Informs future research directions for SNHL prevention and treatment.

Keywords:
diabetes mellitusendothelial dysfunctionsensorineural hearing loss

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