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Does COVID-19 cause or worsen LUT dysfunction, what are the mechanisms and possible treatments? ICI-RS 2023
Vik Khullar1, Berni Lemmon1, Omer Acar2
1Department of Urogynaecology, St Mary's Hospital, Imperial College, London, UK.
Neurourology and Urodynamics
|March 20, 2024
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and can lead to lower urinary tract symptoms (LUTS). This review discusses the virus
Area of Science:
- Urology
- Virology
- Immunology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic.
- The virus can impact the lower urinary tract (LUT), causing bladder inflammation and lower urinary tract symptoms (LUTS).
- LUTS can manifest in both acute and chronic phases of COVID-19.
Purpose of the Study:
- To review and discuss the literature on COVID-19 and bladder dysfunction.
- To explore the pathophysiology of LUTS associated with SARS-CoV-2 infection.
- To identify research questions for future investigation.
Main Methods:
- Literature review presented at the 2023 International Consultation on Incontinence-Research Society (ICI-RS) meeting.
- Discussion focused on reported LUTS and their underlying pathophysiology.
- Exploration of viral infection mechanisms affecting the urinary tract.
Main Results:
- COVID-19 infection is linked to various lower urinary tract symptoms.
- Pathophysiological mechanisms for acute and chronic LUTS in COVID-19 patients were discussed.
- The interaction between SARS-CoV-2 and the immune system in causing LUTS was examined.
Conclusions:
- Evidence supports theories linking viral infection and immune response to acute and chronic LUTS.
- Further research is needed to fully understand COVID-19's impact on the lower urinary tract.
- Key research questions regarding SARS-CoV-2 and bladder dysfunction were identified.
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