Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

396
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
396
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

307
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
307
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

285
The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
285
Causality in Epidemiology01:21

Causality in Epidemiology

409
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
409

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural study on human placentae from women subjected to assisted reproductive technology treatments.

Biology of reproduction·2011
Same author

Intravenous busulfan-cyclophosphamide as a preparative regimen before allogeneic hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2011
Same author

Lathyrane diterpenoids from the roots of Euphorbia micractina and their biological activities.

Journal of natural products·2011
Same author

Quantification of sofalcone in human plasma and urine by high performance liquid chromatography-mass spectrometry.

Journal of pharmaceutical and biomedical analysis·2011
Same author

A densely overlapping gene fragmentation approach improves yeast two-hybrid screens for Plasmodium falciparum proteins.

Molecular and biochemical parasitology·2011
Same author

Seedling growth and metal accumulation of selected woody species in copper and lead/zinc mine tailings.

Journal of environmental sciences (China)·2011
Same journal

LncRNA EGOT inhibits the proliferation of lung adenocarcinoma cells and is associated with poor prognosis.

Nucleosides, nucleotides & nucleic acids·2026
Same journal

Can the combination of 5-fluorouracil and gemcitabine increase the treatment efficacy of pancreatic and colon cancer?

Nucleosides, nucleotides & nucleic acids·2026
Same journal

"Aptamer-guided therapeutics and diagnostics for metabolic syndrome: Design, delivery, and translation of aptamer-based systems".

Nucleosides, nucleotides & nucleic acids·2026
Same journal

The impact of vitamin B12 deficiency on urinary profile of <i>de novo</i> purine synthesis intermediates: consequences of the methylfolate trap.

Nucleosides, nucleotides & nucleic acids·2026
Same journal

Evaluation of MTH1 and DCTPP1 inhibitors in fluorocyclopentenylcytosine (RX-3117) resistant lung cancer cells and potential cross resistance patterns.

Nucleosides, nucleotides & nucleic acids·2026
Same journal

Circular RNAs: promising biomarkers for diagnosis, prognosis and therapy in oral squamous cell carcinoma.

Nucleosides, nucleotides & nucleic acids·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

Causal relationship between irritability and asthma: a bidirectional two-sample Mendelian randomization study.

Xiaoying Lu1, Xu Hu1, Ling Wang1

  • 1Department of Respiratory and Critical Care Medicine, Ziyang Central Hospital, Ziyang, Sichuan, China.

Nucleosides, Nucleotides & Nucleic Acids
|March 20, 2024
PubMed
Summary
This summary is machine-generated.

Irritability significantly increases asthma risk, according to Mendelian randomization analysis. Gastroesophageal reflux disease may mediate this association, highlighting a potential pathway for intervention in asthma prevention.

Keywords:
IrritabilityMendelian randomizationasthmagastroesophageal reflux diseasegenome-wide association studies

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

22.5K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.4K

Related Experiment Videos

Last Updated: Jun 30, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

22.5K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.4K

Area of Science:

  • Genetics
  • Epidemiology
  • Psychiatry

Background:

  • Previous research suggests a link between negative emotional states and asthma.
  • Understanding the causal relationship between psychological factors and respiratory conditions is crucial for public health.

Purpose of the Study:

  • To investigate the potential causal relationship between irritability and asthma using a two-sample Mendelian randomization (MR) approach.
  • To explore the role of gastroesophageal reflux disease (GERD) as a potential mediator in the irritability-asthma association.

Main Methods:

  • Utilized genome-wide association studies (GWAS) data to identify instrumental variables (IVs) for irritability.
  • Employed inverse-variance weighting (IVW) and weighted median (WME) methods for MR analysis.
  • Conducted sensitivity analyses, including the leave-one-out method, to ensure result robustness.

Main Results:

  • Mendelian randomization analysis indicated that irritability is a significant risk factor for asthma (IVW: OR=1.954, p=0.008; WME: OR=1.934, p=0.021).
  • Gastroesophageal reflux disease (GERD) was identified as a potential mediator, possibly explaining about 40% of the observed association.
  • Sensitivity analyses confirmed the stability and reliability of the findings.

Conclusions:

  • Irritability causally increases the risk of developing asthma.
  • GERD may play a significant mediating role in the pathway linking irritability to asthma.
  • These findings suggest potential therapeutic targets for asthma management by addressing irritability and GERD.