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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Persistent Fatigue in Patients With Hepatocellular Carcinoma Receiving Radiotherapy.

Chiao-Yi Chen1, Bing-Shen Huang2, Ji-Hong Hong3

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Fatigue in hepatocellular carcinoma (HCC) patients receiving radiation therapy persists long after treatment ends. Lower income, poorer function, pain, and psychological distress worsen this radiotherapy-related fatigue.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Hepatocellular Carcinoma Research

Background:

  • Hepatocellular carcinoma (HCC) treatment often involves radiation therapy.
  • Radiotherapy-related fatigue in HCC patients is understudied.

Purpose of the Study:

  • To investigate the temporal changes in fatigue among HCC patients undergoing radiotherapy.
  • To identify factors associated with fatigue during and after treatment.

Main Methods:

  • Prospective longitudinal study of 100 HCC patients.
  • Symptom assessment using validated scales at five time points (pre-therapy to 6 months post-therapy).
  • Statistical analysis using generalized estimating equations.

Main Results:

  • Fatigue levels significantly increased during and after radiotherapy compared to baseline.
  • Lower income, poorer functional status, worse pain, and psychological symptoms were linked to increased fatigue.
  • Fatigue did not return to pre-therapy levels within six months post-treatment.

Conclusions:

  • Persistent fatigue is a significant issue for HCC patients after radiotherapy.
  • Regular fatigue assessment is crucial for these patients.
  • Addressing pain and psychological distress is vital for managing radiotherapy-related fatigue.