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Updated: Jun 30, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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Epigenetic regulation of TGF-β pathway and its role in radiation response

Yunan Ding1, Guangming Zhou1, Wentao Hu1

  • 1State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.

International Journal of Radiation Biology
|March 20, 2024
PubMed
Abstract

Insights

Transforming growth factor-beta (TGF-β) influences tumor progression and radiation response. Understanding TGF-β-mediated epigenetic regulation in radiotherapy can reveal new therapeutic targets for improved cancer treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Radiation Biology

Background:

  • Transforming growth factor-beta (TGF-β) has a complex role in tumor progression and is crucial for radiation response.
  • Epigenetic mechanisms, including DNA methylation and histone modifications, are implicated in TGF-β's influence on tumor development and radiation sensitivity.

Purpose of the Study:

  • To elucidate the epigenetic mechanisms underlying TGF-β-mediated radiation response.
  • To explore the impact of TGF-β signaling on radiation-induced effects.
  • To identify potential therapeutic targets for enhancing radiotherapy.

Main Methods:

  • Review of existing literature on TGF-β signaling, epigenetics, and radiotherapy.
  • Analysis of epigenetic modifications (DNA methylation, histone modifications, non-coding RNAs) in the context of TGF-β and radiation.
  • Identification of potential adjuvant strategies and therapeutic targets.

Main Results:

  • TGF-β signaling pathways are significantly modulated by epigenetic factors in cancer.
  • Epigenetic regulations by TGF-β impact both tumor progression and response to radiation therapy.
  • Specific epigenetic mechanisms offer potential targets for combination therapies.

Conclusions:

  • Understanding TGF-β-related epigenetic regulation is key to improving radiotherapy outcomes.
  • Targeting these epigenetic mechanisms may enhance the efficacy of radiation treatment.
  • This knowledge provides a basis for developing novel therapeutic strategies in oncology.
Keywords:
Transforming growth factor (TGF-β)histone modificationionizing radiationmethylationnon-coding RNA

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