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Effects of mitochondrial transplantation on chronic pressure wound healing in a human patient
Omer Faruk Taner1, Oner Ulger2, Simay Ersahin3
1Department of Plastic Surgery, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Background Aims:
Wound healing is a multistage process that requires a concerted effort of various cell types. The intricate processes involved in the healing of wounds result in high energy requirements. Furthermore, mitochondria play a crucial role in the healing process because of their involvement in neo angiogenesis, growth factor synthesis, and cell differentiation. It is unclear how mitochondria transplantation, a promising new approach, influences wound healing.
Methods:
In this study, healthy autologous mitochondria obtained from skeletal muscle were injected into chronic pressure wounds as an intervention to promote wound healing.
Results:
Mitochondrial transplantation accelerated wound healing by reducing wound size, increasing granulation tissue, and hastening epithelialization.
Conclusions:
This study is the first to demonstrate the therapeutic efficacy of mitochondrial transplantation in wound healing.
