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Kidney damage relates to agonal bacteremia: a single-center retrospective study
Yumiko Mikami1, Meiko Ogawa2, Yuuki Hayasaka1
1Clinical Laboratory Department, St. Luke's International University, 9-1 Akashi-Cho, Chuo-City, Tokyo, Japan.
Clinical and Experimental Nephrology
|March 20, 2024
Summary
Premortem kidney damage significantly increases the likelihood of agonal bacteremia, a condition identified through postmortem blood cultures. This finding highlights the link between pre-existing organ damage and postmortem infections.
Area of Science:
- Forensic Pathology
- Microbiology
- Nephrology
Background:
- Agonal bacteremia, detected via postmortem blood cultures, is a potential factor in mortality.
- Premortem organ damage may exacerbate agonal bacteremia.
Purpose of the Study:
- To investigate the relationship between premortem organ damage and agonal bacteremia.
- To determine if kidney damage influences the incidence of agonal bacteremia.
Main Methods:
- A postmortem study involving blood and alveolar fluid cultures from 30 cadavers.
- Evaluation of clinical parameters and organ damage (brain, heart, lung, kidney, liver, gastrointestinal tract) in relation to blood culture results.
Main Results:
- Blood cultures were positive in 76.7% of cases.
- Agonal bacteremia was significantly higher in cases with heart damage (100%) and kidney damage (100%).
- The mean number of cultured species increased significantly with the number of damaged organs, particularly heart and kidney.
Conclusions:
- Premortem kidney damage is directly related to agonal bacteremia.
- The extent of organ damage correlates with the severity of agonal bacteremia.
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