Reliable biological and multi-omics research through biometrology

Area of Science:

• Biometrology
• Metrology
• Biological Measurement Science

Background:

• Biological and multi-omics research often suffers from irreproducibility across different labs and methods.
• This inconsistency hinders the translation of research findings into clinical applications.
• A key factor is the limited adherence to general metrology principles by biologists.

Purpose of the Study:

• To review the progress of biometrology in nucleic acid, protein, and cell measurements.
• To assess the impact of biometrology on the reliability and comparability of biological research.
• To discuss challenges and future directions in biometrology for improved biological measurements.

Main Methods:

• Review of advancements in metrology for nucleic acid, protein, and cell measurements.
• Analysis of the impact of these advancements on research reliability.
• Discussion of current challenges and future strategies in biometrology.

Main Results:

• Biometrology has shown progress in standardizing measurements for nucleic acids, proteins, and cells.
• Improvements in metrological traceability, reference procedures, and materials enhance data reliability.
• Challenges remain in establishing primary reference procedures and new standards for biological reference materials.

Conclusions:

• Establishing reliable reference measurement procedures is crucial for biometrology.
• Developing comprehensive reference materials, from single to multi-omics scales, is essential.
• Adopting a biometrology mindset is vital for translating high-throughput omics research into clinical practice.