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Updated: Jun 30, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Effect of apolipoprotein E (APOE) gene polymorphisms on the lipid profile of children being treated for acute
Maria Ioannidou1, Chrysostomos Avgeros2, Elisavet Georgiou2
1Pediatric and Adolescent Hematology Oncology Unit, 2nd Department of Pediatrics, Faculty of Health Sciences, School of Medicine, AHEPA University General Hospital, Aristotle University of Thessaloniki, St. Kyriakidi 1, 54621, Thessaloniki, Greece. ioannidou@auth.gr.
Background:
Medications used to treat acute lymphoblastic leukemia (ALL), such as L-asparaginase, can cause blood lipid disturbances. These can also be associated with polymorphisms of the lipoprotein lipase (LpL) and apolipoprotein E (APOE) genes.
Procedure:
We aimed to investigate the association between lipid profile, certain LpL and APOE gene polymorphisms (rs268, rs328, rs1801177 and rs7412, rs429358 respectively) as well as the risk subgroup in 30 pediatric patients being treated for ALL, compared with 30 pediatric ALL survivors and 30 healthy controls.
Results:
The only APOE gene polymorphism with significant allelic and genotypic heterogeneity was rs429358. Further analysis of this polymorphism showed that genotype (CC, CT, or TT) was significantly associated with (1) changes in the lipid profile at the end of consolidation (total cholesterol, LDL, apo-B100, and lipoprotein a) and during re-induction (total cholesterol and apo-B100), and (2) classification in the high risk-ALL subgroup (for CC genotype/C allele presence).
Conclusions:
Lipid abnormalities in children being treated for ALL may be associated with the APOE genotype, which is also possibly associated with risk stratification. Further research is needed to confirm the potential prognostic value of these findings.
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