Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Cancer Survival Analysis01:21

Cancer Survival Analysis

345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of dexmedetomidine on emergence agitation and pain in post-anesthesia recovery of patients undergoing upper limb elective orthopedic surgery: a double-blind randomized clinical trial.

BMC anesthesiology·2026
Same author

Helicobacter pylori infection and liver function alterations in individuals undergoing gastric cancer screening: a cohort study.

Scientific reports·2026
Same author

Prophylactic Role of Ketamine and Dexmedetomidine on the Prevention of Shivering in Patients Undergoing Inguinal Herniorrhaphy by Spinal Anesthesia: A Randomized Clinical Trial.

Anesthesiology and pain medicine·2026
Same author

A rare case of primary hydatid cyst of the adrenal gland: Case report and review of the literature.

International journal of surgery case reports·2025
Same author

A rare case report of triple primary malignancies: synchronous breast ductal invasive carcinoma and lung neuroendocrine tumor, followed by chronic myeloid leukemia.

International journal of surgery case reports·2025
Same author

Evaluation of the thyroid and hypothyroid function after postoperative radiation therapy among breast cancer patients.

Canadian oncology nursing journal = Revue canadienne de nursing oncologique·2024

Related Experiment Video

Updated: Jun 30, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.0K

Histopathological Feature of Early-Onset Breast Cancer: A Comparative Analysis.

Iraj Feizi1, Khatereh Isazadehfar2, Farshid Sadegzadeh3

  • 1Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

The International Tinnitus Journal
|March 20, 2024
PubMed
Summary

Younger women diagnosed with breast cancer show higher rates of lymph node involvement. This suggests an earlier age at diagnosis is linked to a poorer prognosis, even with similar tumor staging.

Keywords:
Age groupAxillary lymph nodeBreast cancerHistologyPathology

More Related Videos

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
11:47

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer

Published on: February 8, 2013

11.9K
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

12.6K

Related Experiment Videos

Last Updated: Jun 30, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
11:12

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

8.0K
Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
11:47

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer

Published on: February 8, 2013

11.9K
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

12.6K

Area of Science:

  • Oncology
  • Pathology
  • Women's Health

Background:

  • Breast cancer is a prevalent malignancy in women, with earlier diagnoses often correlating with worse prognoses.
  • Factors contributing to poorer outcomes in younger breast cancer patients include advanced disease stage and delayed presentation.
  • Existing research presents varied findings, necessitating further investigation into age-related histopathological differences.

Purpose of the Study:

  • To investigate and compare breast cancer histopathology in women under and over 40 years old.
  • To analyze age-specific differences in axillary lymph node involvement in breast cancer patients.

Main Methods:

  • A cross-sectional study involving 64 breast cancer patients diagnosed between 2014 and 2015.
  • Histopathological data were collected from patient records.
  • Axillary lymph node involvement was assessed and compared between two age groups (under 40 and over 40) with similar tumor (T) staging.

Main Results:

  • The study included 64 patients; 71.9% were over 40 and 28.1% were under 40.
  • Invasive ductal carcinoma was the most common tumor type.
  • Significantly higher axillary lymph node involvement was observed in patients under 40 compared to those over 40, even at equivalent tumor stages (T=1, T=2).

Conclusions:

  • Patients under 40 years old with breast cancer exhibit a higher rate of axillary lymph node metastasis at comparable tumor stages.
  • This finding supports the association between early-onset breast cancer and a more aggressive disease course, indicating a worse prognosis.
  • Age is a critical factor influencing breast cancer progression and outcomes.