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Asthma and chronic obstructive pulmonary disease (COPD) in people with multiple sclerosis: A systematic review and
Hamed Ghoshouni1, Nazanin Rafiei2, Mohammad Yazdan Panah3
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Background:
Studies have found that multiple sclerosis (MS) has an impact on the initiation or the course of asthma and chronic obstructive pulmonary disease (COPD). This review amied to investigate the prevalence and odds of asthma and COPD among people with MS (pwMS).
Method:
PubMed, Embase, Scopus, and Web of Science were systemically searched from inception to May 2023. R version 4.3.2 and random-effect model were used to calculate the pooled prevalence and odds ratio (OR), with their 95 % confidence interval (CI), in pwMS.
Results:
A total of 40 studies consisting of 287,702 pwMS were included. 37 studies indicated that the pooled prevalences of asthma and COPD among pwMS were 5.97 % (95 % CI: 4.62 %-7.69 %, I2=99 %) and 3.03 % (95 % CI: 1.82 %-5.00 %, I2=99 %), respectively. 24 studies on 236,469 pwMS and 85,328,673 healthy controls revealed that the overall odds of asthma and COPD in MS were 1.14 (95 % CI: 0.76-1.71, p-value=0.53, I2=97 %) and 1.28 (95 % CI: 1.11-1.47, p-value<0.01, I2=70 %), respectively.
Conclusion:
MS can increased the risk of developing COPD, while asthma does not exhibit a significant relationship with MS. Our study highlights the importance of identifying pwMS who face greater risks of respiratory issues to monitor efficiently and initiate suitable preventative actions.
Insights
Multiple sclerosis (MS) increases the risk of developing chronic obstructive pulmonary disease (COPD). However, MS does not show a significant link with asthma. Early identification of MS patients with respiratory risks is crucial for timely intervention.
Area of Science:
- Neurology
- Pulmonology
- Epidemiology
Background:
- Multiple sclerosis (MS) is known to affect the onset and progression of respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD).
- Understanding the prevalence and risk of these respiratory diseases in people with MS (pwMS) is essential for comprehensive patient care.
Conclusions:
- The findings indicate that MS is associated with an increased risk of developing COPD, but not asthma.
- This highlights the need for proactive respiratory health monitoring in individuals with MS.
- Identifying pwMS at higher risk for respiratory complications can facilitate targeted preventative strategies and management.
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