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Updated: Jun 30, 2025

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NUF2 regulated the progression of hepatocellular carcinoma through modulating the PI3K/AKT pathway via stabilizing

Yiwei Liu1, Yuming Wang1, Jifei Wang1

  • 1Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), Nanjing, China; Jiangsu Provincial Medical Innovation Center; Jiangsu Provincial Medical Key Laboratory, Nanjing, China.

Translational Oncology
|March 20, 2024
PubMed
Summary

NUF2, a protein in hepatocellular carcinoma (HCC), promotes cancer growth by stabilizing ERBB3 and activating the PI3K/AKT pathway. Inhibiting NUF2 offers a potential therapeutic strategy for HCC.

Keywords:
ERBB3HCCNUF2PI3K/AKTUbiquitination

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