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Insulin biotrapping using plasmofluidic optical fiber chips: A benchmark.

Médéric Loyez1, Hadrien Fasseaux2, Maxime Lobry2

  • 1Proteomics and Microbiology Department, University of Mons (UMONS), 7000, Belgium; Electromagnetism and Telecom. Department, University of Mons (UMONS), 7000, Belgium.

Biosensors & Bioelectronics
|March 20, 2024
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Summary

This study compares plasmonic optical fiber biosensors with traditional prism-based sensors. Fiber-based sensors show comparable reliability and an enhanced limit of detection for improved biosensing applications.

Keywords:
BiacoreBiosensorInsulin detectionOptical fiberPlasmonicsTilted fiber bragg grating (TFBG)

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Optical Physics

Background:

  • Plasmonic optical fiber biosensors are emerging technologies for practical applications.
  • Current biosensors often use multimode optical fibers and white light.
  • This work focuses on single-mode optical fibers with tilted fiber Bragg gratings (TFBGs) in the near-infrared range.

Purpose of the Study:

  • To enhance surface sensitivity and sensing capabilities of optical fiber-based biosensors.
  • To develop in situ sensing with remote interrogation capabilities.
  • To compare the performance of TFBG-based biosensors against a commercial prism-based plasmonic sensor.

Main Methods:

  • Utilized single-mode optical fibers coupled with tilted fiber Bragg gratings (TFBGs).
  • Employed a near-infrared wavelength range for enhanced sensitivity.
  • Assessed performance using refractive index sensitivity and insulin sensing via microfluidics.
  • Optimized a surface biotrapping methodology for consistent measurements.

Main Results:

  • Demonstrated comparable experimental trends between TFBG-based and prism-based configurations.
  • Showcased enhanced limit of detection for gold-coated TFBGs compared to the commercial device.
  • Highlighted remarkable sensitivity to variations in bulk and surface properties for both technologies.
  • Validated the reliability of optical fiber-based measurements.

Conclusions:

  • Optical fiber-based plasmonic biosensors offer a reliable alternative to traditional methods.
  • TFBG-based sensors provide enhanced sensitivity and a lower limit of detection.
  • This research paves the way for detecting localized molecular interactions and events on optical probe surfaces.