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Updated: Jun 30, 2025
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Published on: August 20, 2018
Progress on synthesis and structure-activity relationships of lamellarins over the past decade
Mingze Wei1, Jing Chen1, Yuliang Song1
1School of Pharmaceutical Science, Zhejiang Chinese Medical University, 310061, Hangzhou, China.
Abstract:
Lamellarins are polyaromatic alkaloids isolated from marine organisms, including mollusks, tunicates, and sponges. Currently, over 60 structurally distinct natural lamellarins have been reported, and most of them exhibit promising biological activities, such as topoisomerase inhibition, mitochondrial function inhibition, multidrug resistance reversing, and anti-HIV activity. There has also been a significant progress on the synthetic study of lamellarins which has been regularly updated by numerous medicinal chemists as well. This review provides a detailed summary of the synthesis, pharmacology, and structural modification of lamellarins over the past decades.
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