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Updated: Jun 30, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Management of Clostridioides difficile Infection: Diagnosis, Treatment, and Future Perspectives
Michael Cymbal1, Arjun Chatterjee1, Brian Baggott2
1Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio.
Abstract:
Clostridioides difficile infection is the most common healthcare-associated infection in the United States, with potential life-threatening complications and a significant impact on the costs of care. Antibiotic stewardship as well as discontinuation of chronic acid suppressive therapy are key for its prevention and treatment. Effective infection management requires appropriate interpretation of diagnostic tests, as well as the use of vancomycin and fidaxomicin as first-line treatment. Novel treatments such as Bezlotoxumab, fecal microbiota transplant, and live biotherapeutic products are proven effective in recurrent C. difficile infection and address dysbiosis.
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