Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CAR19 Tregs treat murine chronic Graft-Versus-Host Disease through immune suppression in absence of measurable B-cell cytolysis.

JCI insight·2026
Same author

Contribution of HMGB1 to keratinocyte inflammation in recessive dystrophic epidermolysis bullosa.

JID innovations : skin science from molecules to population health·2026
Same author

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Incidence of Post-Sedation Emesis in Cynomolgus (<i>Macaca fascicularis</i>) and Rhesus (<i>Macaca mulatta</i>) Macaques, and Evaluation of Prophylactic Antiemetic Efficacy.

Animals : an open access journal from MDPI·2025
Same author

Patient education series: understanding trauma and emergency surgical conditions-emergency general surgery and the emergency general surgeon.

Trauma surgery & acute care open·2025
Same author

Contribution of HMGB1 to Keratinocyte inflammation in Recessive Dystrophic Epidermolysis Bullosa.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jun 30, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice
06:55

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

12.3K

Methods for Decreasing Preweaning Mortality in a Fragile Mouse Model of Hypomorphic Collagen VII Deficiency.

Chloe L Strege1, William C Miller1, Cindy Eide1

  • 1Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, Minnesota.

Comparative Medicine
|March 20, 2024
PubMed
Summary

Improving laboratory mouse survival requires specialized care for fragile mouse models. This study enhanced standard husbandry with diet, bedding, and handling changes, successfully increasing survival rates in a specific fragile mouse strain.

More Related Videos

Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

607
Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

3.3K

Related Experiment Videos

Last Updated: Jun 30, 2025

Bioengineering Human Microvascular Networks in Immunodeficient Mice
06:55

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

12.3K
Tricolor Transgenic Murine Model for Studying Growth Plate Injury
07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

607
Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

3.3K

Area of Science:

  • Laboratory animal science
  • Genetics
  • Animal husbandry

Background:

  • Preweaning mortality is a significant issue in laboratory mouse breeding, especially for fragile mouse models.
  • Limited research exists on specialized care for genetically compromised mouse strains.

Purpose of the Study:

  • To develop and evaluate an enhanced care plan to improve the survival of fragile laboratory mice.
  • To identify adaptable care strategies for various fragile mouse strains.

Main Methods:

  • Modified standard husbandry by incorporating a softened diet, nutritional supplements, soft bedding, and gentle handling.
  • Reduced handling frequency and extended weaning age.
  • Implemented dam productivity tracking.

Main Results:

  • The enhanced care plan significantly increased the survival rate of a fragile recessive dystrophic epidermolysis bullosa mouse model.
  • Demonstrated the efficacy of specific interventions like diet modification and gentle handling.

Conclusions:

  • An integrated approach to husbandry, including diet, bedding, and handling, can improve survival in fragile mouse models.
  • The developed care strategies offer a foundation for managing other genetically compromised mouse strains.