Related Experiment Video
Updated: Jun 30, 2025
06:04
Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
8.9K
Association between inflammation and post-intensive care syndrome: a systematic review
C Docherty1, C Page2, J Wilson3
1Academic Unit of Anaesthesia, Critical Care and Peri-operative Medicine, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
Anaesthesia
|March 20, 2024
Summary
Inflammation may be linked to long-term symptoms after critical illness, but evidence is mixed. More research is needed to understand the inflammatory profile of intensive care unit survivors and its impact on recovery.
Area of Science:
- Critical care medicine
- Neuroscience
- Immunology
Background:
- Post-intensive care syndrome (PICS) encompasses persistent physical, cognitive, and emotional deficits after critical illness.
- Pathological mechanisms underlying PICS remain poorly understood.
- This review investigates the link between inflammation and PICS features in critical illness survivors.
Approach:
- Systematic review of studies on human participants exposed to critical illness.
- Searched for studies reporting inflammation biomarkers and PICS outcomes.
- Included 32 studies (23 primary analysis, 9 subgroup analysis).
Key Points:
- 47 biomarkers and 44 outcome measures were analyzed.
- Interleukin-8, C-reactive protein, and interleukin-10 showed frequent associations with PICS.
- Significant variability existed in biomarker selection, timing, and outcome measures.
Conclusions:
- Evidence for a direct association between inflammation and long-term PICS outcomes is mixed.
- Further high-quality research is required to establish longitudinal inflammatory profiles in survivors.
- Longitudinal studies are crucial for evaluating the impact of inflammation on critical illness recovery.
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