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A Novel Application of Musculoskeletal Ultrasound Imaging

A Novel Application of Musculoskeletal Ultrasound Imaging

Published on: September 17, 2013

Explorative study using ultrasound time-harmonic elastography for stiffness-based quantification of skeletal muscle

Yang Yang¹, Mehrgan Shahryari¹, Tom Meyer¹

¹Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Zeitschrift Fur Medizinische Physik

|March 20, 2024

Summary

Time-harmonic elastography (THE) allows rapid, full-field mapping of skeletal muscle stiffness. This study shows THE can quantify muscle-specific stiffness changes during isometric exercise, offering new insights into muscle function.

Keywords:

Isometric Contraction/Exercise Musculoskeletal System Stiffness Time-Harmonic Elastography Ultrasound Elastography

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Published on: December 14, 2020

Area of Science:

Biomedical Engineering
Musculoskeletal Imaging
Ultrasound Technology

Background:

Time-harmonic elastography (THE) is an advanced ultrasound technique for mapping tissue stiffness.
Previous applications of THE have not focused on skeletal muscle's temporal stiffness changes.
There is a need to understand dynamic stiffness variations across different muscles during exertion.

Purpose of the Study:

To apply THE for simultaneous, real-time stiffness quantification of multiple skeletal muscles.
To investigate temporal changes in muscle stiffness during isometric preloading, loading, and postloading phases.
To analyze shear-wave speed (SWS) and its standard deviation (SD) as indicators of muscle stiffness and contraction regulation.

Main Methods:

Acquired repeated THE scans every five seconds in ten healthy volunteers.
Quantified shear-wave speed (SWS) and SWS standard deviation (SD) for the biceps brachii (long and short heads) and brachialis muscles.
Measured SWS and SD during a 3-min preloading phase, a 3-min loading phase (4, 8, 12 kg), and a 9-min postloading phase.

Main Results:

Preloading stiffness (SWS) and stiffness increase with load were muscle-specific (p < 0.001).
SWS increased continuously during loading (0.022 m/s/min, p < 0.01) and exhibited an average relaxation time of 27 seconds postloading.
Muscle-specific SWS SD at preloading (p < 0.05) increased with load (p < 0.01) and decreased immediately postloading.

Conclusions:

THE is a promising technique for in vivo, real-time quantification of skeletal muscle stiffness and its dynamic changes.
Temporal variations in muscle stiffness during isometric exercise may reflect muscle functional status.
THE provides complementary information to conventional morphological imaging for skeletal muscle assessment.