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Regulation of m6Am RNA modification and its implications in human diseases

Hao Jin1,2, Zhouyuanjing Shi3, Tianhua Zhou2,3,4

  • 1Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

Journal of Molecular Cell Biology
|March 20, 2024
PubMed

Insights

N6,2'-O-dimethyladenosine (m6Am) is a key RNA modification regulating gene expression. This review covers m6Am enzymes, detection, and its role in diseases like obesity, viral infections, and cancer.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • RNA Biology

Background:

  • N6,2"-O-dimethyladenosine (m6Am) is a prevalent epitranscriptomic modification found on mRNA and snRNA.
  • This reversible modification is regulated by specific methyltransferases and demethylases.
  • m6Am plays critical roles in gene expression by influencing splicing, mRNA stability, and translation.

Purpose of the Study:

  • To provide a comprehensive overview of N6,2 -O-dimethyladenosine (m6Am) research.
  • To detail m6Am-modifying enzymes and detection methodologies.
  • To explore the functional impacts and disease relevance of m6Am.

Main Methods:

  • Literature review of m6Am-related studies.
  • Analysis of m6Am-modifying enzymes (methyltransferases and demethylases).
  • Examination of sequencing approaches for m6Am detection.

Main Results:

  • m6Am influences pre-mRNA splicing, mRNA stability, and translation.
  • The modification is implicated in the pathogenesis of obesity, viral infections, and cancers.
  • Understanding m6Am regulatory mechanisms is crucial for disease insights.

Conclusions:

  • m6Am is a significant epitranscriptomic mark with broad biological functions.
  • Further research into m6Am is vital for understanding its role in human health and disease.
  • Targeting m6Am pathways may offer therapeutic strategies for diseases like cancer.
Keywords:
cancergene regulationm6Am RNA modificationobesityviral infection

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