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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Deciphering the interplay between psychopathological symptoms, sensorimotor, cognitive and global functioning: a

Stefan Fritze¹, Geva A Brandt¹, Sebastian Volkmer^1,2

¹Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159, Mannheim, Germany.

European Archives of Psychiatry and Clinical Neuroscience

|March 21, 2024

Summary

Sensorimotor and cognitive impairments are closely linked in schizophrenia spectrum and mood disorder patients, suggesting shared pathophysiology. Sensorimotor symptoms may be a transdiagnostic treatment target, but further research with balanced groups is needed.

Keywords:

Cognitive domain Network analysis Psychopathology Sensorimotor domain Transdiagnostic

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Area of Science:

Neuroscience
Psychiatry
Clinical Psychology

Background:

Understanding the link between psychopathology and neurobehavioral functioning can reveal new treatment targets.
Limited research exists on the interrelationship of symptoms, sensorimotor, cognitive, and global functioning in transdiagnostic samples.
This study hypothesized a strong connection between sensorimotor and cognitive functioning in a transdiagnostic patient group.

Purpose of the Study:

To investigate the interplay and centrality of psychopathological symptoms, sensorimotor, cognitive, and global functioning.
To examine these relationships in a transdiagnostic sample of patients with schizophrenia spectrum disorders (SSD) and mood disorders (MOD).

Main Methods:

Network analysis and community detection were applied to a sample of 212 patients (174 SSD, 38 MOD).
Assessments included the Positive and Negative Syndrome Scale (PANSS), Heidelberg Neurological Soft Signs Scale (NSS), Global Assessment of Functioning (GAF), and a Brief Cognitive Assessment Tool (TMT-B, CF, DSST).

Main Results:

Sensorimotor (NSS) and cognitive (TMT-B, CF, DSST) functions showed stronger connections than with global functioning (GAF) or psychopathology (PANSS).
Digit Symbol Substitution Test (DSST), PANSS general, and NSS motor coordination exhibited the highest expected influence (EI).
Sensory integration, DSST, and category fluency (CF) demonstrated the highest strength.

Conclusions:

The findings indicate a close relationship between sensorimotor and cognitive impairments, suggesting shared pathophysiology in SSD and MOD.
High centrality of sensorimotor symptoms points to their potential as a transdiagnostic therapeutic target.
Further studies with more balanced diagnostic groups are necessary to confirm sensorimotor symptoms as a transdiagnostic target.