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Related Experiment Videos

Leucocyte ascorbate levels and postoperative deep venous thrombosis.

T V Taylor, A T Raftery, J B Elder

    The British Journal of Surgery
    |August 1, 1979
    PubMed
    Summary

    Preoperative vitamin C (ascorbic acid) did not reduce deep venous thrombosis (DVT) incidence. However, leucocyte ascorbic acid concentration (LAC) levels were lower in DVT patients postoperatively, suggesting a role in DVT pathogenesis.

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    Area of Science:

    • Surgical Research
    • Nutritional Science
    • Vascular Medicine

    Background:

    • Deep venous thrombosis (DVT) is a common postoperative complication.
    • The role of vitamin C in DVT prevention and pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate if preoperative ascorbic acid supplementation reduces postoperative DVT incidence.
    • To examine the relationship between leucocyte ascorbic acid concentration (LAC) and DVT development.

    Main Methods:

    • Prospective, randomized, double-blind, placebo-controlled trial.
    • 44 general surgical patients received ascorbic acid (500 mg b.d.) or placebo for 7 days preoperatively.
    • Leucocyte ascorbic acid concentration (LAC) measured pre- and postoperatively; DVT diagnosed via 125I-fibrinogen test and leg scans.

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    Main Results:

    • No significant difference in DVT incidence between ascorbic acid and placebo groups.
    • Mean LAC on the day of operation did not differ between DVT and non-DVT groups.
    • Significantly lower LAC levels observed on postoperative days 6 and 9 in patients who developed DVT.

    Conclusions:

    • Preoperative ascorbic acid administration does not decrease postoperative DVT incidence.
    • Decreased LAC levels in DVT patients suggest a potential role for leucocyte adherence in DVT pathogenesis.
    • Further research is warranted to explore vitamin C's role in DVT pathophysiology.