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Updated: May 5, 2026
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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
Published on: February 27, 2011
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Development and advancements in rodent MRI-based brain atlases
Xiaoyi Ma1, Yao Xing2,3, Renkuan Zhai3
1Department of Geriatrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
Heliyon
|March 21, 2024
Summary
This review overviews magnetic resonance imaging (MRI)-based rodent brain atlases, crucial for neuroscience. It addresses the need for standardized MRI brain atlases for mice and rats to advance research.
Area of Science:
- Neuroscience
- Medical Imaging
- Comparative Anatomy
Background:
- Rodents (mice, rats) are vital models in neuroscience research.
- Brain atlases are essential tools, evolving from print to digital imaging formats.
- Magnetic Resonance Imaging (MRI)-based brain atlases offer advanced visualization but face standardization challenges.
Purpose of the Study:
- To provide a comprehensive review of MRI-based rodent brain atlases.
- To compare MRI atlases with traditional histological atlases.
- To guide researchers in selecting and developing standardized MRI brain atlases.
Main Methods:
- Systematic literature review of MRI-based rodent brain atlases.
- Comparative analysis of MRI and histological atlas methodologies.
- Summary of current applications and future directions for MRI brain atlases.
Main Results:
- Multiple MRI brain atlas versions exist, hindering standardization.
- Histological atlases provide detailed cellular information; MRI atlases offer in vivo, non-invasive structural data.
- Standardized methods for MRI atlas creation are emerging.
Conclusions:
- Standardized MRI brain atlases are crucial for reproducible rodent neuroscience research.
- Addressing the current diversity in MRI atlases will facilitate wider adoption and application.
- This review provides a framework for atlas selection and development.
