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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Related Experiment Video

Updated: Jun 30, 2025

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

Published on: July 26, 2024

Microglia-neuron interactions in schizophrenia.

Sophia-Marie Hartmann¹, Johanna Heider¹, Richard Wüst²

¹Molecular Neurobiology, Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.

Frontiers in Cellular Neuroscience

|March 21, 2024

Summary

This summary is machine-generated.

Neuroinflammation involving microglia plays a key role in schizophrenia. Understanding microglia-neuron interactions is crucial for developing anti-inflammatory treatments to alleviate symptoms.

Keywords:

co-culture complement system inflammation microglia neuron schizophrenia synaptic pruning

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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

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Last Updated: Jun 30, 2025

Author Spotlight: In Vitro Co-Culture Model for Studying Microglia-Neuronal Interactions in Disease Conditions

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Published on: July 26, 2024

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Published on: January 30, 2014

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

Area of Science:

Neuroscience
Immunology
Psychiatry

Background:

Neuroinflammation, driven by glial cells, is implicated in schizophrenia.
Microglia, the brain's immune cells, are vital for synaptic development and plasticity.
Genetic and environmental factors may exacerbate microglial activation in schizophrenia.

Purpose of the Study:

To review current findings on microglia-neuron interactions in schizophrenia.
To explore the role of neuroinflammation in schizophrenia pathogenesis.
To discuss potential anti-inflammatory treatments for schizophrenia symptoms.

Main Methods:

Analysis of post-mortem brain tissues.
Review of brain imaging studies.
Examination of animal models and iPSC-derived cell cultures.

Main Results:

Evidence links increased microglial activation and pro-inflammatory cytokines to schizophrenia.
Excessive synaptic pruning by activated microglia contributes to synaptic loss.
Microglia-neuron interactions are a central focus in schizophrenia research.

Conclusions:

Microglia-neuron dysregulation is a significant factor in schizophrenia.
Targeting neuroinflammation presents a promising therapeutic avenue for schizophrenia.
Further research into these interactions could lead to novel treatments.