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Therapeutic proteins: developments, progress, challenges, and future perspectives.

Vimal Kumar1, Arti Barwal2, Nitin Sharma3

  • 1University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab 140413 India.

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|March 21, 2024
PubMed
Summary
This summary is machine-generated.

Therapeutic proteins offer promising treatments for diseases like cancer and diabetes. This review details their sources, production, and challenges, suggesting future combination therapies for enhanced benefits.

Keywords:
ChallengesDiseasesProductionSourcesTherapeutic proteins

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Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Molecular Medicine

Background:

  • Therapeutic proteins are vital for treating diseases including cancer, cardiovascular conditions, and diabetes.
  • Protein-based therapies represent a significant advancement in modern medicine.
  • Challenges in formulation and large-scale production currently limit widespread application.

Purpose of the Study:

  • To provide a comprehensive overview of therapeutic protein sources and production methods.
  • To summarize the key challenges encountered in developing protein-based therapeutics.
  • To explore potential solutions and future directions for protein-based drug development.

Main Methods:

  • Literature review of scientific publications on therapeutic proteins.
  • Analysis of current research on protein formulation, stability, and immunogenicity.
  • Synthesis of information regarding production scalability and cost-effectiveness.

Main Results:

  • Identified diverse sources and established production techniques for therapeutic proteins.
  • Highlighted critical challenges including protein stability, heterogeneity, immunogenicity, and high production costs.
  • Discussed strategies to overcome these developmental hurdles.

Conclusions:

  • Therapeutic proteins hold immense potential across various health sectors.
  • Addressing production and stability challenges is crucial for broader clinical adoption.
  • Future research may focus on combining protein therapeutics with small molecule drugs for synergistic effects.