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Incidence and Risk Factors of Acute Kidney Injury in Pediatric Liver Transplant Patients: A Retrospective Study

Duygu Demiroz1, Yusuf Ziya Colak1, Oya Olcay Ozdes1

  • 1Department of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|March 21, 2024
PubMed

Insights

Acute kidney injury (AKI) in pediatric liver transplant patients is linked to longer surgeries and blood transfusions. Prolonged warm ischemia and operation duration are key risk factors for AKI.

Area of Science:

  • Nephrology
  • Pediatric Surgery
  • Transplantation Medicine

Background:

  • Acute kidney injury (AKI) is a significant complication in pediatric liver transplant (LT) recipients, impacting mortality and morbidity.
  • Understanding AKI's contributing factors and outcomes is crucial for improving patient care.

Observation:

  • A retrospective study analyzed 235 pediatric LT patients (under 18) from 2015-2021.
  • Preoperative and intraoperative variables were assessed for their association with early postoperative AKI.

Findings:

  • Preoperative patient age and albumin levels correlated with AKI development.
  • Surgical duration and intraoperative blood transfusion were significantly associated with AKI.
  • Prolonged warm ischemia time and overall operation duration were identified as independent risk factors for AKI.

Implications:

  • Extended surgical times and increased blood transfusions, especially due to hemodynamic compromise, exacerbate AKI severity.
  • Identifying and mitigating risk factors like prolonged ischemia and surgery duration can potentially reduce AKI incidence and improve outcomes in pediatric LT.
Abstract

Keywords:
Acute kidney injuryLiver transplantationPediatric transplantation

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