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Related Experiment Video

Updated: Jun 19, 2026

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Augmented mannose-binding lectin levels in primary membranous nephropathy: A pilot study.

Deeksha Pal¹, Neeraj Inamdar¹, Prabhjot Kaur¹

¹Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Nephrology (Carlton, Vic.)

|March 21, 2024

Summary

Mannose-binding lectin (MBL) levels are elevated in primary membranous nephropathy (PMN) patients and correlate with endothelial dysfunction. Immunosuppressive therapy reduces MBL levels, suggesting MBL

Keywords:

PLA2R endothelial dysfunction flow mediated dilatation mannose‐binding lectin primary membranous nephropathy

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Published on: August 23, 2024

Area of Science:

Nephrology
Immunology
Cardiovascular Medicine

Background:

Primary membranous nephropathy (PMN) is linked to phospholipase A2 receptor (PLA2R) antibodies, potentially activating the mannose-binding lectin (MBL) cascade.
Aberrant MBL activation may contribute to endothelial dysfunction and cardiovascular disease (CVD) risk in PMN patients.
Research is needed to understand MBL's role in PMN's clinical activity and associated endothelial dysfunction.

Purpose of the Study:

To investigate MBL levels in PMN patients.
To assess the relationship between MBL levels, clinical activity, and endothelial dysfunction in PMN.
To evaluate changes in MBL levels following immunosuppressive therapy.

Main Methods:

MBL levels and flow-mediated vasodilation (FMD) were measured in 22 PMN patients and 22 healthy controls at baseline and after 6 months of therapy.
FMD assessed endothelial function.
Statistical analyses, including Spearman correlation, were used.

Main Results:

PMN patients had significantly higher MBL levels than healthy controls (p < .01).
MBL levels decreased significantly after immunosuppressive therapy (p = .04).
Baseline MBL levels strongly correlated with FMD (ρ = 0.51, p = .01), indicating endothelial dysfunction.

Conclusions:

The findings suggest MBL cascade activation in PMN.
MBL levels are associated with endothelial dysfunction in PMN patients.
MBL may serve as a potential biomarker for cardiovascular risk in PMN.