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Validation of Dynamic 3D MRI for Urodynamics Assessment Using an Anatomically Realistic In Vitro Model of the
James Rice1,2, Wade Bushman3,2, Alejandro Roldán-Alzate4
1Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI 53705; Department of Radiology, University of Wisconsin-Madison, Madison, WI 53705.
Journal of Biomechanical Engineering
|March 21, 2024
Summary
3D dynamic MRI shows potential for noninvasive bladder urodynamics assessment. This study validated the technique using a bladder model, achieving accurate volume and flowrate measurements, paving the way for clinical use.
Area of Science:
- Medical Imaging
- Urology
- Biomedical Engineering
Background:
- Lower urinary tract symptoms (LUTS) significantly impact the aging population.
- Current urodynamic assessment methods present challenges.
- 3D dynamic MRI offers a promising noninvasive approach to bladder assessment.
Purpose of the Study:
- To systematically benchmark the performance of 3D dynamic MRI for urodynamics.
- To validate 3D dynamic MRI against a controlled in vitro model.
- To assess the accuracy of MRI-derived volumetric and flowrate measurements.
Main Methods:
- Development of an anatomically realistic, bladder-mimicking in vitro flow model.
- Utilizing a controllable syringe pump for simulated filling and voiding events.
- Acquisition of time-resolved MRI volumes and simultaneous pressure recordings.
Main Results:
- MRI-derived volumes showed low error (3.36% voiding, 4.66% filling) compared to control.
- MRI-derived flowrates exhibited slight increases in average error (4.90% voiding, 7.67% filling).
- Higher error in segmented volumes correlated with decreased flowrate; pressure changes were accurately captured.
Conclusions:
- 3D dynamic MRI is a validated, noninvasive tool for assessing bladder anatomy and urodynamics.
- The technique demonstrates accuracy in measuring bladder volume and flowrate.
- Further validation with techniques like PIV can enhance understanding of intravesical dynamics.
