Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconsidering Nerve Decompression Surgery in Diabetes Foot Complications.

Journal of the American Podiatric Medical Association·2026
Same author

Quantifying the Phoenix Sign: A Double-Blind Pilot Study on Lidocaine and Papaverine-Induced Vascular and Motor Changes After Common Peroneal Nerve Block in Diabetic Neuropathy.

Journal of the American Podiatric Medical Association·2026
Same author

Is the phoenix sign phenomenon due to vasodilation? A double-blinded, randomized controlled trial comparing motor function recovery after diagnostic common fibular nerve block with lidocaine and papaverine.

BMC musculoskeletal disorders·2024
Same author

Comment on IWGDF ulcer prevention guidelines.

Endocrinology, diabetes & metabolism·2021
Same author

Acute Improvement in Intraoperative EMG During Common Fibular Nerve Decompression in Patients with Symptomatic Diabetic Sensorimotor Peripheral Neuropathy: EMG and Clinical Attribute Interrelations.

Journal of neurological surgery. Part A, Central European neurosurgery·2020
Same author

Acute Improvement in Intraoperative EMG Following Common Fibular Nerve Decompression in Patients with Symptomatic Diabetic Sensorimotor Peripheral Neuropathy: 1. EMG Results.

Journal of neurological surgery. Part A, Central European neurosurgery·2016
Same journal

Adult Burn Survivors Face Elevated Long-Term Risk of Major Adverse Cardiovascular Events, Venous Thromboembolism, and Mortality: A Real-World Analysis.

Advances in wound care·2026
Same journal

Management of Infected Wounds: A Wound Healing Foundation Consensus Statement.

Advances in wound care·2026
Same journal

Predicting Harm: A Systematic Review of Pediatric Pressure Injury Models and Their Clinical Shortcomings.

Advances in wound care·2026
Same journal

Development and Validation of a Novel Risk Prediction Model for Incident Diabetic Foot Complications: A Large, Longitudinal, Population-Based Machine Learning Study.

Advances in wound care·2026
Same journal

Diabetic Foot Ulcers as a Marker of Systemic Disease: Long-Term Survival, Limb Loss, and Economic Impact in a Large Real-World Cohort.

Advances in wound care·2026
Same journal

Temporal <i>In Vitro</i> Models of Skin Wound Healing Components: A Cell-Specific Framework for Acute and Chronic Repair Mechanisms.

Advances in wound care·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2025

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line
04:06

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line

Published on: September 13, 2024

1.9K

Objective Evidence That Nerve Decompression Surgery Reduces Neuropathic DFU Recurrence Risk to Less than 5%

D Scott Nickerson1, Dwayne S Yamasaki2

  • 1NE Wyoming Wound Care Clinic, Sheridan, Wyoming, USA.

Advances in Wound Care
|March 21, 2024
PubMed
Summary
This summary is machine-generated.

Nerve decompression surgery may reduce diabetic foot ulcer recurrence by improving nerve function and blood flow. This approach addresses entrapment neuropathy, offering a potential new therapy for this common complication.

Keywords:
arteriovenous shuntdiabetes entrapment neuropathynerve decompression surgeryneurovascular controlskin microcirculationsympathetic c-fiber damage

More Related Videos

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.6K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.8K

Related Experiment Videos

Last Updated: Jun 30, 2025

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line
04:06

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line

Published on: September 13, 2024

1.9K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

1.6K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.8K

Area of Science:

  • Diabetic medicine
  • Neurology
  • Vascular surgery

Background:

  • Diabetic foot ulcers (DFU) persist despite advances, with high recurrence and complication rates.
  • Standard care (SOC) for DFU has limitations; nerve decompression (ND) shows promise in reducing recurrence.
  • The mechanism behind ND's efficacy in DFU, particularly its impact on microcirculation, is not fully understood.

Purpose of the Study:

  • To elucidate the physiological mechanisms by which nerve decompression (ND) may reduce diabetic foot ulcer (DFU) recurrence.
  • To investigate the role of entrapment neuropathy (EN) and its impact on microcirculation in DPN and DFU.
  • To highlight ND as a potential therapeutic intervention for improving microcirculation in DFU patients.

Main Methods:

  • Review of existing clinical and animal evidence on ND for DFU and diabetic peripheral neuropathy (DPN).
  • Analysis of how ND impacts nerve compression, particularly c-fiber compression in EN.
  • Examination of ND's effects on subepidermal capillary flow, neuromuscular function, and microcirculation phenomena (CCI, PIV).

Main Results:

  • ND alleviates nerve compression in EN, leading to improved subepidermal capillary flow.
  • Studies indicate ND enhances neuromuscular function and epidermal microcirculation, including chronic capillary ischemia (CCI) and pressure-induced vasodilatation (PIV).
  • Evidence suggests releasing compressed peripheral nerves improves sympathetic-controlled epidermal microcirculation.

Conclusions:

  • Epineurolysis for nerve compression is a physiology-based intervention explaining ND's reduced DFU recurrence risk.
  • Integrating ND with SOC could improve outcomes for hard-to-heal ulcers, neuroischemic wounds, and reduce amputation rates.
  • Further Level I evidence-based studies are required to validate ND's efficacy in DFU management.