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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis.

Jiale Wu1, Lihui Yao2, Yuchen Liu1

  • 1Department of Oral and Maxillofacial Surgery, Peking University School of Medicine, Hospital of Stomatology, Beijing, China.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|March 21, 2024
PubMed
Summary

This study investigated if periodontitis causes osteoporosis using genetic data. Mendelian randomization analysis found no significant causal link between periodontitis and increased osteoporosis risk.

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Area of Science:

  • Genetics
  • Epidemiology
  • Oral Health
  • Bone Metabolism

Background:

  • Rising global incidences of periodontitis and osteoporosis.
  • Observational studies suggest a link between periodontitis and increased osteoporosis risk.

Purpose of the Study:

  • To genetically investigate the causal relationship between periodontitis and osteoporosis.
  • To determine if periodontitis causally increases the risk of developing osteoporosis.

Main Methods:

  • Mendelian randomization (MR) study utilizing 9 single nucleotide polymorphisms (SNPs) associated with periodontitis.
  • Primary analysis employed the inverse variance-weighted (IVW) method.
  • Sensitivity analyses included simple median, weighted median, penalized weighted median, and MR-Egger regression.

Main Results:

  • No significant causal effect of genetically predicted periodontitis on osteoporosis risk was found using IVW (fixed and random effects) or other sensitivity analyses.
  • MR-Egger regression showed no evidence of pleiotropic effects (P=0.101).
  • Leave-one-out analysis confirmed no single SNP unduly influenced the results.

Conclusions:

  • The Mendelian randomization analysis does not support a significant causal effect of periodontitis on the risk of osteoporosis.
  • Further research may be needed to fully elucidate the complex relationship between these two conditions.