Related Experiment Video
Updated: Jun 30, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset
Maria Pia Campagna1, Eva Kubala Havrdova2, Dana Horakova2
1Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Background:
The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity.
Methods:
We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity.
Results:
Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05).
Conclusion:
These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs

