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Related Concept Videos

Centrioles and Centrosomes01:13

Centrioles and Centrosomes

2.7K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
2.7K
Centrosome Duplication02:25

Centrosome Duplication

4.0K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
4.0K
Histone Variants at the Centromere02:30

Histone Variants at the Centromere

4.3K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
4.3K
The Mitotic Spindle02:27

The Mitotic Spindle

6.6K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
6.6K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

3.3K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.3K
Attachment of Sister Chromatids02:57

Attachment of Sister Chromatids

3.3K
As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules.  Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...
3.3K

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Related Experiment Video

Updated: Jun 30, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

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Positioning centrioles and centrosomes.

Matthew R Hannaford1, Nasser M Rusan1

  • 1Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

The Journal of Cell Biology
|March 21, 2024
PubMed
Summary

Centrosomes organize microtubules and position cilia. Their intracellular transport is crucial, as mispositioning links to diseases like cancer and infertility.

Area of Science:

  • Cell Biology
  • Molecular Motors
  • Cytoskeleton Dynamics

Background:

  • Centrosomes are key microtubule-organizing centers in eukaryotic cells.
  • Proper centrosome localization is essential for cell structure, division, and cilia/flagella formation.
  • Centrosome mispositioning is implicated in various human diseases, including ciliopathies, cancer, and infertility.

Approach:

  • This review synthesizes current knowledge on centrosome motility mechanisms.
  • It explores both indirect (motor proteins acting on centrosomal microtubules) and direct (centrosome as motor cargo) transport pathways.
  • The review discusses the functional consequences of centrosome mispositioning.

Key Points:

  • Centrosome intracellular transport is vital for cellular organization and function.

More Related Videos

Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

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Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles
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Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles

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Related Experiment Videos

Last Updated: Jun 30, 2025

Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.0K
Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes

Published on: December 20, 2014

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Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles
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Isolation and Fluorescence Imaging for Single-particle Reconstruction of Chlamydomonas Centrioles

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  • Two main modes of motor-driven transport exist: indirect and direct.
  • Dysregulation of centrosome positioning contributes to significant pathologies.

    • Conclusions:

    • Understanding centrosome motility is critical for addressing diseases linked to its mispositioning.
    • Further research is needed to fully elucidate the complex mechanisms governing centrosome transport.
    • Identifying remaining questions in centrosome motility and mispositioning is a key goal.