Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prenatal immunization against experimental enteric colibacillosis in piglets.

C C Gay

    Canadian Journal of Comparative Medicine : Revue Canadienne De Medecine Comparee
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systemic alterations induced by a Bothrops alternatus hemorrhagic metalloproteinase (baltergin) in mice.

    Toxicon : official journal of the International Society on Toxinology·2008
    Same author

    Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom.

    Toxicon : official journal of the International Society on Toxinology·2005
    Same author

    Effects of biotin supplementation on performance and claw lesions on a commercial dairy farm.

    Journal of dairy science·2004
    Same author

    Multiresistant Salmonella Typhimurium DT104 infections of humans and domestic animals in the Pacific Northwest of the United States.

    Epidemiology and infection·2000
    Same author

    Fecal Escherichia coli O157:H7 shedding patterns of orally inoculated calves.

    Veterinary microbiology·1999
    Same author

    Regulation of the immunoglobulin G1 receptor: effect of prolactin on in vivo expression of the bovine mammary immunoglobulin G1 receptor.

    The Journal of endocrinology·1999

    Prenatal immunization against Escherichia coli (E. coli) showed partial protection in piglets but was significantly hindered by intrauterine deaths in vaccinated litters, complicating model development.

    Area of Science:

    • Veterinary immunology
    • Swine disease models
    • Maternal immunization

    Background:

    • Enteric colibacillosis, caused by Escherichia coli, is a significant neonatal swine disease.
    • Effective immunization strategies are crucial for controlling piglet morbidity and mortality.
    • Prenatal immunization offers a potential route to induce early-life immunity.

    Purpose of the Study:

    • To develop a model for studying prenatal immunization against enteric colibacillosis in piglets.
    • To evaluate the efficacy of in utero immunization against Escherichia coli.
    • To assess the safety and feasibility of prenatal vaccination in sows.

    Main Methods:

    • Seven sows were immunized 18–22 days before term via intra-amniotic and intramuscular injection of Escherichia coli antigen.

    Related Experiment Videos

  • Progeny litters were challenged at birth with homologous or heterologous strains of Escherichia coli.
  • Outcomes included protection against challenge and incidence of intrauterine death.

    • Main Results:

    • Partial protection against homologous Escherichia coli challenge was observed in some vaccinated piglets.
    • A significant proportion of vaccinated piglets experienced intrauterine death, compromising the study.
    • The immunization model demonstrated challenges in establishing reliable prenatal immunity.

    Conclusions:

    • Prenatal immunization against enteric colibacillosis in piglets yielded mixed results.
    • Intrauterine death in vaccinated piglets poses a significant limitation to this immunization model.
    • Further research is needed to refine prenatal vaccination strategies and overcome safety concerns.