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Related Experiment Videos

Studies on experimental enteric salmonellosis in ponies.

R Owen, J N Fullerton, I R Tizard

    Canadian Journal of Comparative Medicine : Revue Canadienne De Medecine Comparee
    |July 1, 1979
    PubMed
    Summary

    This study details Salmonella typhimurium infection in ponies, noting fever and low white blood cell counts correlating with bacterial shedding. Age influences salmonella agglutination titres in horses.

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    Area of Science:

    • Veterinary Medicine
    • Infectious Diseases
    • Equine Health

    Background:

    • Salmonella typhimurium is a significant pathogen in equids.
    • Understanding its clinical manifestations and diagnostic markers is crucial for disease management.

    Purpose of the Study:

    • To investigate the clinical, bacteriological, serological, and haematological responses of ponies experimentally infected with Salmonella typhimurium.
    • To compare these responses with control and accidentally infected ponies.
    • To explore the correlation between age and serological titres in clinically normal horses.

    Main Methods:

    • Oral inoculation of adult ponies with Salmonella typhimurium.
    • Monitoring clinical signs, rectal fecal shedding, and serological and haematological parameters.

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  • Necropsy examination of infected ponies.
  • Serological testing of clinically normal horses.

    • Main Results:

    • Inoculated ponies exhibited pyrexia and neutropaenia, followed by neutrophilia, coinciding with maximal bacterial shedding.
    • Faecal changes were observed early post-inoculation and linked to serological responses.
    • Positive colon cultures at necropsy were found in ponies with negative rectal faecal cultures.
    • A correlation between age and Salmonella agglutination titre was identified in horses.

    Conclusions:

    • Clinical and haematological changes in ponies are associated with Salmonella typhimurium shedding.
    • Rectal faecal culture may not always detect infection in the colon.
    • Age is a factor in serological detection of Salmonella in horses.