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Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation
1Department of Biomolecular Science and Engineering, University of California, Santa Barbara, CA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|March 21, 2024
Abstract:
Protein liquid-liquid phase separation (LLPS) has been associated with protein amyloid aggregation. Amyloid aggregation of tau is a hallmark of Alzheimer's disease and other neurodegenerative diseases. This protocol provides steps to prepare tau condensates via LLPS, so that researchers can further study its driving forces and its relationship with tau amyloid aggregation.
