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Updated: Jun 30, 2025
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
A Brain Ischemia-Reperfusion Model for the Study of Tau Phosphorylation and O-GlcNAcylation
Alejandro Vera-González1, Carlos F Cardozo2,3, Elisa Viveros Araque3
1Universidad de Caldas - Grupo de Neurociencia de Caldas, Manizales, Colombia.
Abstract:
Cerebral ischemia produces a decrease, loss, or instability of the assembly processes in the neuronal cytoskeleton, related to the alteration in the normal processes of phosphorylation of the Tau protein, triggering its hyperphosphorylation and altering the normal processes of formation of neuronal microtubules. Here we describe the methods used to study the impact of middle cerebral artery occlusion (MCAo) on neurological functions and Tau phosphorylation in Wistar rat brain.
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