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Cumulative blood pressure predicts risk of stroke in individuals with type 2 diabetes

Rukai Yang1, Hejun Jiang1, Zhenhua Xing1

  • 1Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China.

Diabetes & Metabolic Syndrome
|March 21, 2024
PubMed

Insights

Cumulative systolic blood pressure (SBP) effectively predicts stroke in type 2 diabetes (T2D) patients. This measure offers greater predictive insight than baseline BP alone for stroke risk in T2D.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Epidemiology

Background:

  • Type 2 Diabetes (T2D) significantly increases cardiovascular disease risk.
  • Stroke is a major complication in individuals with T2D.
  • Accurate prediction of stroke risk is crucial for effective management in T2D patients.

Purpose of the Study:

  • To investigate the predictive capability of cumulative blood pressure (BP) for stroke incidence in individuals with T2D.
  • To compare the predictive value of cumulative BP with baseline BP measurements for stroke risk.

Main Methods:

  • Analysis of data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
  • Inclusion of participants without prior stroke history.
  • Assessment of cumulative BP elevations and evaluation using multivariate-adjusted Cox proportional hazard models.

Main Results:

  • 8282 participants (62.10% male, mean age 62.73 years) were analyzed.
  • Cumulative systolic BP (SBP) and pulse pressure independently predicted stroke events.
  • A significant dose-response relationship was observed between cumulative BP and stroke risk.

Conclusions:

  • Cumulative SBP is an independent predictor of stroke in individuals with T2D.
  • Cumulative SBP provides incremental predictive value beyond baseline BP assessments for stroke risk.
Abstract

Keywords:
Blood pressureCardiovascular diseasesCumulative exposureHypertensionStrokeType 2 diabetes

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